Bronchodilatory effect of deep inspiration in freshly isolated sheep lungs
نویسندگان
چکیده
منابع مشابه
Bronchodilatory effect of deep inspiration on the dynamics of bronchoconstriction in mice.
We recently developed a computational model of an airway embedded in elastic parenchyma (Bates JH, Lauzon AM. J Appl Physiol 102: 1912-1920, 2007) that accurately mimics the time dependence of airway resistance on tidal volume and positive end-expiratory pressure (PEEP) following methacholine injection in normal animals. In the present study, we compared the model predictions of bronchodilation...
متن کاملBronchodilatory effect of deep inspiration is absent in subjects with mild COPD.
STUDY OBJECTIVES To investigate whether the bronchodilatory effect of deep inspiration is impaired in subjects with COPD. METHODS We measured deep inspiration-induced bronchodilation in 19 patients with COPD and 17 healthy subjects (mean age, 67.8 +/- 7.1 years vs 62.5 +/- 9.3 years, respectively [+/- SEM]). Each subject underwent a series of single-dose methacholine provocations to induce at...
متن کاملAssociation between reduced bronchodilatory effect of deep inspiration and loss of alveolar attachments
BACKGROUND We have previously shown that the bronchodilatory effect of deep inspiration is attenuated in individuals with COPD. This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments. METHODS We measured deep inspiration (DI)-induced bronchodilation in 15 individuals with and without COPD (67 +/- 2.2 yrs of age, mean +/- SE...
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in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
Bronchodilatory response to deep inspiration in bronchial segments: the effects of stress vs. strain.
During deep inspirations (DI), a distending force is applied to airway smooth muscle (ASM; i.e., stress) and the muscle is lengthened (i.e., strain), which produces a transient reversal of bronchoconstriction (i.e., bronchodilation). The aim of the present study was to determine whether an increase in ASM stress or the accompanying increase in strain mediates the bronchodilatory response to DI....
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2017
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00321.2016